Doxiproct ointment is used for all hemorrhoidal degrees: in 1st and 2nd degree for treatment due to Calcium dobesilate and in 3rd and 4th degree as adjuvant to surgery. First-degree internal hemorrhoids do not protrude, cannot be palpated by digital examination, and require anoscopy for diagnosis.
Second-degree hemorrhoids protrude with defecation, but reduce spontaneously.
Third-degree hemorrhoids protrude and require manual reduction.
Fourth-degree hemorrhoids are irreducibly prolapsed.

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