This medication is used to temporarily relieve eye redness, puffiness, itching and watering that commonly occur with allergies. Naphazoline is a decongestant. It belongs to a class of drugs known as sympathomimetic amines. It works by temporarily narrowing the blood vessels in the eye. It is an antihistamine eye drop that provides temporary relief of red, itchy eyes due to ragweed, pollen, grass, animal dander and hair.