Twynsta is a fixed dose combination of Telmisartan and Amlodipine. It is a prescription Medicine used to treat the symptoms of high blood pressure (Hypertension).Telmisartan is an angiotensin receptor blocker (ARB) and amlodipine is a calcium channel blocker. They both work differently to relax the blood vessels so that blood can flow more easily. Twynsta may be used alone or with other medications.